Cellular Neurobiology

We are working on the cellular and molecular basis of neurological diseases with emphasis on Parkinson's disease, signaling by Gq-coupled receptor and phosphoinositide metabolism. 

Research projects

Aggregate transport and clearance

Several neurodegenerative disorders are characterized (and potentially caused) by protein aggregates - e.g. Parkinson's disease by aggregates of α-synuclein. We have previously found that cells sequester α-synuclein aggregates into aggresomes, which can then be cleared from the cell entirely (Opazo et al., 2009). In an IZKF-funded project we will identify new potential therapeutic targets for aggregopathies by studying the molecular components that constitute this pathway using biophysical measurements and molecular tools in single, living cells.

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